ti -Tyrosine Hydroxylase Mouse mAb

價(jià)格：在線咨詢

貨號：

KT011753

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Tyrosine Hydroxylase mouse monoclonal antibody
Protein full name	Tyrosine 3-monooxygenase
Synonyms	TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase
Immunogen	Recombinant protein corresponding to Mouse Tyrosine Hydroxylase
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Axon
Uniprot ID	P24529,P04177

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Mouse, Rat	1: 500-1: 3000	brain, corpus striatum, substantia nigra

Background

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen(O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene,and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases(AAAHs).

Images

	Immunohistochemistry of paraffin embedded mouse brain using TH (GB12181) at dilution of 1: 1500 (400x lens)
	Immunohistochemistry of paraffin embedded rat brain using TH (GB12181) at dilution of 1: 1500 (400x lens)
	Immunofluorescence of paraffin embedded mouse corpus striatum using TH (GB12181) at dilution of 1: 500 (400x lens)
	Immunofluorescence of paraffin embedded mouse substantia nigra using TH (GB12181) at dilution of 1: 500 (400x lens)
	Immunofluorescence of paraffin embedded rat substantia nigra using TH (GB12181) at dilution of 1: 500 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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