Anti -Notch1 Rabbit pAb

價格：在線咨詢

貨號：

KT011815

產品規(guī)格：

100 μL

Applications：

Species：

H/M/R

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	Notch1 rabbit polyclonal antibody
Protein full name	Neurogenic locus notch homolog protein 1
Synonyms	Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, TAN1, 9930111A19Rik, AOVD1, AOS5
Immunogen	KLH conjugated Synthetic peptide corresponding to Human Notch1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	273 kDa
Observed MW.	120 kDa
Uniprot ID	P46531, Q01705, Q07008

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 400-1: 800	brain, liver, cortex

Background

NOTCH1, also named as TAN1, belongs to the NOTCH family. NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. It may be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. NOTCH1 is involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle.

Images

Picture 1.png

Western blot analysis of Notch1 (GB111690) at dilution of 1: 400

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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