The protein encoded by this gene is a member of the keratin gene family. The Krt6 belongs to type II cytokeratins and consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin(KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita.
Images
Western blot analysis of CK6 (GB111247) at dilution of 1: 1000
Lane 1: A431 cell lysate
Lane 2: Mouse skin tissue lysate
Immunohistochemistry analysis of paraffin-embedded human tonsil using CK6 (GB111247) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded mouse skin using CK6 (GB111247) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat skin using CK6 (GB111247) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat stomach using CK6 (GB111247) at dilution of 1: 1000
Immunofluorescent analysis of paraformaldehyde-fixed mouse skin using CK6 (GB111247) at dilution of 1: 1000
Immunofluorescent analysis of paraformaldehyde-fixed rat stomach using CK6 (GB111247) at dilution of 1: 1000
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer
PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .