HsMCU, Coiled-coil domain-containing protein 109A, MCU, C10orf42, CCDC109A
Immunogen
Recombinant protein corresponding to Mouse MCU
Isotype
IgG
Purity
Affinity purification
Predicted MW.
40 kDa
Observed MW.
30-35 kDa
Uniprot ID
Q8NE86, Q3UMR5
Applications
Applications
Species
Dilution
Positive Sample
WB
Human, Mouse
1: 500-1: 800
PANC-1, A549, NIH/3T3
Background
MCU, also known as CCDC109A, is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) . The MCU protein is composed of two coiled-coil domains, two TMDs, and a short motif of amino acids between the two TMDs. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.
Images
Western blot analysis of MCU (GB111353) at dilution of 1: 500
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .