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Anti -PFKL Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
KT011973
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC
Species:
H
購(gòu)買數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information


Description

PFKL rabbit polyclonal antibody

Protein full name

ATP-dependent 6-phosphofructokinase, liver type

Synonyms

ATP-PFK, PFK-L, PFK-B, PFKL, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B

Immunogen

Recombinant protein corresponding to Human PFKL

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

P17858




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human

1: 1000-1: 3000

hepatocarcinoma, liver, prostate




Background


PFKL is the Liver isozyme of PFK (Phosphofructokinase), which is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate by ATP. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.




Images


Picture 1.png

Immunohistochemistry of paraffin embedded human hepatocarcinoma using pfk1 (GB111136) at dilution of 1:1600 (400x lens)

Picture 2.png Immunohistochemistry of paraffin embedded human liver using pfk1 (GB111136) at dilution of 1:1600 (400x lens)

Picture 3.png

Immunohistochemistry of paraffin embedded human prostate using pfk1 (GB111136) at dilution of 1:1600 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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