Anti -Insulin degrading enzyme / IDE Rabbit pAb

價格：在線咨詢

貨號：

KT012025

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

H/M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	IDE rabbit polyclonal antibody
Protein full name	Insulin-degrading enzyme
Synonyms	Insulin protease, Insulinase, Insulysin, Ide, FLJ35968, Abeta-degrading protease
Immunogen	Recombinant protein corresponding to Mouse IDE
Isotype	IgG
Purity	Affinity purification
Predicted MW.	118 kDa
Observed MW.	120 kDa
Uniprot ID	P14735, Q9JHR7, P35559

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 500-1: 1000	brain, skeletal muscle, colon

Background

IDE(Insulin-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a neutral metallopeptidase that Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism.

Images

Picture 1.png

Western blot analysis of IDE (GB111387) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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