Anti -MRPL12 Rabbit pAb

價格：在線咨詢

貨號：

KT012098

產(chǎn)品規(guī)格：

100 μL

Applications：

WB | IHC

Species：

M,R/H

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	MRPL12 rabbit polyclonal
Protein full name	39S ribosomal protein L12, mitochondrial
Synonyms	L12mt, MRP-L12, 5c5-2, Mitochondrial large ribosomal subunitprotein bL12m, MRPL12, MRPL7, RPML12
Immunogen	KLH conjugated Synthetic peptide corresponding to Human MRPL12
Isotype	IgG
Purity	Affinity purification
Subcellular location	Mitochondrion
Predicted MW.	21 kDa
Observed MW.	21 kDa
Uniprot ID	Q9DB15

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	stomach, colon, breast
IHC	Human	1: 500-1: 1000	stomach cancer

Background

MRPL12 is a component of the 39S subunit of mammalian mitochondrial ribosomes, and is encoded by a nuclear gene. The protein forms a homodimer, localizes predominantly to mitochondria and binds to the large mitochondrial ribosomal subunit. It is required for CycD/Cdk4- induced cell growth. In addition, forming a ribosomal stalk with MRPL7, MRPL12 is required for the recruitment of translation elongation factors Tu and G to the large ribosomal subunit . It also a part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation and/or ribosome biogenesis during human mitochondrial gene expression.

Images

Western blot analysis of MRPL12 (GB111410) at dilution of 1: 1000

Lane 1: Mouse stomach tissue lysate

Lane 2: Mouse colon tissue lysate

Lane 3: Rat breast tissue lysate

Lane 4: Rat stomach tissue lysate

Immunohistochemistry analysis of paraffin-embedded human stomach cancer using MRPL12 (GB111410) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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