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Anti -BRCA2 Rabbit pAb

價格: 在線咨詢
貨號:
KT012103
產(chǎn)品規(guī)格:
100ul
Applications:
IHC/IF
Species:
M/R
購買數(shù)量:
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Product Information


Description

BRCA2 rabbit polyclonal antibody

Protein full name

Breast cancer type 2 susceptibility protein

Synonyms

Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated

Immunogen

Recombinant protein corresponding to Mouse BRCA2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

P97929, O35923




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Mouse, Rat

1:1500-1:3000

brain, hippocampus




Background


BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation.




Images


Picture 1.png

Immunohistochemistry of paraffin embedded mouse hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens)

Picture 2.png

Immunohistochemistry of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:1100 (400x lens)

Picture 3.png

Immunofluorescence of paraffin embedded mouse brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens)

Picture 4.png

Immunofluorescence of paraffin embedded rat brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens)

Picture 5.png

Immunofluorescence of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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