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Anti -Lamin A + Lamin C Rabbit pAb

價格: 在線咨詢
貨號:
KT012163
產(chǎn)品規(guī)格:
100ul
Applications:
WB
Species:
M
購買數(shù)量:
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Product Information


Description

Lamin A + Lamin C rabbit polyclonal antibody

Protein full name

Prelamin-A/C

Synonyms

Lamin-A/C, Lmna, Lmn1, Cardiomyopathy dilated 1A (autosomal dominant), LGMD1B, LFP, LMNA, Renal carcinoma antigen NYREN32

Immunogen

Recombinant protein corresponding to Mouse Lamin A + Lamin C

Isotype

IgG

Purity

Affinity purification

Predicted MW.

74 kDa

Observed MW.

74 kDa

Uniprot ID

P48678




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse

1: 500-1: 1000

liver, colon



Background


The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.




Images


Picture 1.png

Western blot analysis of LaminAC (GB112400) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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