Anti -MDM2 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101286

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC

Species：

M,R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	MDM2 rabbit polyclonal
Protein full name	E3 ubiquitin-protein ligase Mdm2
Synonyms	Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse MDM2
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Uniprot ID	P23804

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 1000-1: 3000	lung, kidney, thymus

Background

MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Over expression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse lung using MDM2 (GB111161) at dilution of 1: 1500
	Immunohistochemistry analysis of paraffin-embedded rat lung using DM2 (GB111161) at dilution of 1: 1500
	Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDM2 (GB111161) at dilution of 1: 1500
	Immunohistochemistry analysis of paraffin-embedded rat kidney using MDM2 (GB111161) at dilution of 1: 1500
	Immunohistochemistry analysis of paraffin-embedded mouse thymus using MDM2 (GB111161) at dilution of 1: 1500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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