Anti -GBA Rabbit pAb

價格：在線咨詢

貨號：

KT011511

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC、IF

Species：

M,R | M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	GBA rabbit polyclonal
Protein full name	Lysosomal acid glucosylceramidase
Synonyms	GBA, GBA1, GCB, GLUC, Glucosylceramidase beta, Glucocerebrosidase, BETA GLUCOSIDASE, ACID, Gba protein
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse GBA
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm
Uniprot ID	P17439

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 1000-1: 2000	kidney, stomach, small intestine, fetal rat
IF	Mouse, Rat	1: 500-1: 1000	kidney, stomach, small intestine, fetal rat

Background

The GBA is a glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism . May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol . The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol .

Images

	Immunohistochemistry analysis of paraffin-embedded mouse kidney using GBA (GB111110) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat kidney using GBA (GB111110) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse stomach using GBA (GB111110) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat small intestine using GBA (GB111110) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse fetal rat using GBA (GB111110) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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