Anti -CDKN2A/p16INK4a Rabbit pAb

價格：在線咨詢

貨號：

KT011828

產品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	CDKN2A/p16INK4a rabbit polyclonal antibody
Protein full name	Cyclin-dependent kinase inhibitor 2A
Synonyms	Cyclin-dependent kinase 4 inhibitor A, CDK4I, CDKN2A, MTS1, CDKN2 , Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16INK4A, p16-INK4
Immunogen	KLH conjugated Synthetic peptide corresponding to Human CDKN2A/p16INK4a
Isotype	IgG
Purity	Affinity purification
Predicted MW.	17 kDa
Observed MW.	17 kDa
Uniprot ID	P42771

Applications

Applications	Species	Dilution	Positive Sample
WB	Human	1: 500-1: 1000	HeLa, Saso-2, 293T, HepG2, HEK293

Background

This gene generates several transcript variants which differ in their first exons.There are at least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon and this transcript contains an alternate open reading frame (ARF) that ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Images

Western blot analysis of p16 (GB111605) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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