Anti -Rb2 p130 Rabbit pAb

價格：在線咨詢

貨號：

KT011843

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Rb2 p130 rabbit polyclonal antibody
Protein full name	Retinoblastoma-like protein 2
Synonyms	130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, Rbl2
Immunogen	Recombinant protein corresponding to Mouse Rb2 p130
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus?
Uniprot ID	Q64700, O55081

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Mouse, Rat	1: 500-1: 1500	brain, testis

Background

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

Images

	Immunofluorescence of paraffin embedded mouse brain using kb12 (GB111770) at dilution of 1:700 (300x lens)
	Immunofluorescence of paraffin embedded rat testis using kb12 (GB111770) at dilution of 1:700 (260x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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