Anti -MRP1 Rabbit pAb

價格：在線咨詢

貨號：

KT011987

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

R/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	MRP1 rabbit polyclonal
Protein full name	Multidrug resistance-associated protein 1
Synonyms	ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, Abcc1, Mrp1, LTC4 transporter
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse MRP1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane
Uniprot ID	Q8CG09

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Rat	1: 800-1: 1600	lymphoid, brain
IF	Rat	1: 400-1: 800	lymphoid, brain

Background

MRP1 is a member of the MRP subfamily of ATPbindingcassette (ABC) transporters . MRP1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agent sand the glutathione (GSH) conjugates of these compounds. MRP1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids,leukotrienes and prostaglandins. Although MRP1 is generally expressed in normaltissue, upregulation of MRP1 has been found in avariety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer . Research studies show that over expression of MRP1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1 is predictive of the response and toxicity of chemotherapeutic agents in those patients.

Images

	Immunohistochemistry analysis of paraffin-embedded rat lymphoid usingMRP1 (GB111041) at dilution of 1: 1600
	Immunohistochemistry analysis of paraffin-embedded rat brain using MRP1 (GB111041) at dilution of 1: 1600

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

凡合肥萬物生物科技有限公司銷售的產(chǎn)品均有嚴格的質(zhì)量保證。如發(fā)現(xiàn)產(chǎn)品存在包裝規(guī)格疑問，請于收貨之日起七日內(nèi)向我公司總部或當(dāng)?shù)剞k事處提出，并請保證該產(chǎn)品，以備本公司進行核對檢驗。如果發(fā)現(xiàn)有質(zhì)量問題，請于收貨后一月內(nèi)保留產(chǎn)品50%以上的量，以便本公司回收產(chǎn)品進行質(zhì)檢，確認產(chǎn)品質(zhì)量。如逾期，則視為已經(jīng)對本公司產(chǎn)品進行驗收。聲明：如發(fā)生產(chǎn)品索賠事宜，本公司僅在產(chǎn)品價格范圍內(nèi)酌情賠償，恕不接受超出產(chǎn)品價格范圍之賠償?？蛻粼谑褂眠^程中有任何技術(shù)問題可以撥打技術(shù)售后服務(wù)電話我們隨時給予解答。

合肥萬物生物科技有限公司

客服熱線：400-1016-218

QQ：355185756

地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學(xué)科技園A401室