DA transporter, DAT, Solute carrier family 6 member 3, Slc6a3, Dat, Dat1
Immunogen
Recombinant protein corresponding to Mouse Dopamine Transporter
Isotype
IgG
Purity
Affinity purification
Predicted MW.
69 kDa
Observed MW.
69 kDa
Uniprot ID
Q61327, P23977
Applications
Applications
Species
Dilution
Positive Sample
WB
Mouse, Rat
1: 500-1: 1000
brain, cortex, hippocampus, cerebellum
Background
DAT1, also known as SLC6A3 and Sodium-dependent dopamine transporter, is a sodium and chloride-dependent dopamine transporter belonging to the solute carrier family 6. Dopamine transporters are distributed widely across the brain in regions with high dopaminergic activity, such as the striatum and substantia nigra. These transporters effectively provide fast acting clearance of dopamine, adrenalin and noradrenalin from the synaptic cleft, thus terminating the neurotransmitter signal. DATs have been found to interact with PRKCABP, TGFB1I1, SLC18A2 and the N-terminus of SYNGR3. DATs are also the target proteins for psychomotor stimulants such as amphetamines and cocaine. Research has implicated DATs as useful markers in detecting depression, schizophrenia, Parkinson's disease and drug abuse.
Images
Western blot analysis of SLC6A3 (GB111215) at dilution of 1: 500
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .