Anti -BNIP3 Rabbit pAb

價格：在線咨詢

貨號：

KT012193

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

H/M

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	BNIP3 rabbit polyclonal antibody
Protein full name	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Synonyms	Bnip3, Nip3
Immunogen	Recombinant protein corresponding to Mouse BNIP3
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm
Uniprot ID	Q12983, O55003

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Human, Mouse	1: 1000-1: 2000	breast cancer, colon cancer, spleen, testis

Background

The BNIP3 is an apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Images

	Immunohistochemistry of paraffin embedded human breast cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens)
	Immunohistochemistry of paraffin embedded human colon cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse spleen using BNIP3 (GB111204) at dilution of 1:1000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse testis using BNIP3 (GB111204) at dilution of 1:1000 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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